Description
Recent advances in ultra-intense laser technology have enabled the production of high-energy electron beams in the GeV range through laser-driven acceleration. These sources offer unique properties, such as ultra-short pulse duration and extremely high dose rates, making them highly relevant for biomedical and radiobiological applications, particularly in the context of FLASH irradiation.
This work aims to explore the biomedical potential of laser-driven GeV electrons by investigating their interaction with biological matter and their effects on advanced in-vitro cellular models. The study focuses on the characterization and optimization of electron beam parameters (over 10 GeV), including stability, reproducibility, and dose delivery around 10¹¹ Gy/s, in order to establish controlled and reliable irradiation conditions for biological experiments. Dedicated irradiation setups and dosimetry strategies will be developed to ensure accurate correlation between physical beam properties and biological outcomes. An integrated experimental approach will be implemented, combining high-resolution cellular microscopy with time-resolved optical spectroscopy to enable in-situ and real-time monitoring of radiation-induced effects. This methodology will allow the investigation of cellular morphology, biochemical composition, and dynamic processes following ultra-high dose-rate irradiation. Emphasis will be placed on understanding the biological response mechanisms associated with FLASH conditions and on identifying potential biomarkers of radiation response.
The results of this study are expected to contribute to a deeper understanding of radiobiological effects under extreme irradiation regimes and to assess the feasibility of laser-driven GeV electrons for future biomedical applications. Ultimately, this research will support the development of innovative laser-based platforms for radiobiology studies and may inform the design of next-generation radiation therapy and diagnostic approaches.
